As a PLATFORM for SYSTEMS BIOLOGY, the open-source project LIFE123 (https://life123.science) offers a growing set of tools to wrestle with the complications of numerical solutions to complex dynamical systems, such as cycles of biochemical reactions. ONLY 1/2 OF THE BATTLE, is to offer functions to set up and simulate webs...
Every poignant dramatic story has an arch-villain. The aging process has many! A well-known one is chronic inflammation - sometimes referred to as "Inflammaging" (the vicious cycle between inflammation and aging.) An often-discussed source of chronic inflammation are senescent cells - but they aren't the only one. The N...
BioAge Labs CANTOS Cell Biology Healthspan IL-18 IL-1β Inflammaging InflammasomesInflammation Life123 Longevity NLRP3 PharmacologyPyroptosis
Hello everyone I hope you are fine and doing great. I am a fresh graduate of Microbiology (Food and Nutrition). I want to hunt a postdoc in my research domain (Microbiome, Probiotics, Genomics). As per my research and collected information, the postdoc positions are competitive and the ones with a high number of pertinent ...
Once in a while, a paper gives a feeling of "Wow, at a junction in History!" Such is a recent entry in Nature Cell Biology, which I will liken to a play: Prelude - Telomere (DNA protective caps) shortening : one of the first recognized "hallmarks of aging"... (general background from NIH: https://www.ncbi.nlm.nih.gov/pmc/...
Protoplasm isolation is a recurrent technique that is needed for the transfection of plant tissue culture and the evaluation of transiently expressed genetic vectors. This is a widely used technique in many plant development labs. However further adaptation might require adjustments on either more recalcitrant salt and buff...
Something I love about scientific conferences is being exposed to less widely known - but potentially very important - avenues of research. Case in point: the accumulation of a toxic biomolecule, an oxidized form of cholesterol (7-ketocholesterol : https://pubchem.ncbi.nlm.nih.gov/compound/7-Ketocholesterol ), believed to ...
7-ketocholesterol Atherosclerosis Candymer software Cell BiologyCholesterolConferences Cyclarity Therapeutics Cyclodextrins Ending Age-Related Diseases 2022 Healthspan Longevity Matthew O'Connor Pharmacology UDP-003
GOAL : To develop a safe and effective gene therapy vector! So excited and thankful to share these preliminary results. I am sharing this on youtube in more detail! https://youtu.be/twwOipz50WM In S/MAR vector the best promoter/terminator combination to use for gene expression is Ef1A/BGH in HepG2cells. As also demonst...
Mainstream media is having a field day - paywalled news reports on Wall St Journal, etc. Cutting thru the hype, I think a worthwhile general-public report is https://www.reuters.com/lifestyle/science/scientists-find-clues-what-makes-immortal-jellyfish-immortal-2022-08-29/ It leaves out plenty - but the original paper is f...
Cell BiologyJellyfish Life cycle reversal Longevity PRC2 Turritopsis dohrnii
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