New breakthrough CRISPR and WNT

Saw this on Twitter... From the abstract

To study Dvl’s role in Wnt signaling, we genome engineered an endogenously expressed Dvl2 protein tagged with an mEos3.2 fluorescent protein for superresolution imaging… Our results indicate that the localization of Dvl2 in supramolecular condensates is coordinated dynamically and dependent on cell state and Wnt signaling levels. Our study highlights the formation of endogenous and physiologically regulated biomolecular condensates in the Wnt pathways at single-molecule resolution.

While this is interesting to look at, does anyone else wonder if this process could have a more widespread application? Or does it solely work for Dvl2??


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Matteo Sorrentino4 months ago

Hm, I would assume so… I think this is supposed to work with any proteins that are more light sensitive, i guess? tbh i just gave it a quick look through

Maddie Watts4 months ago

Well, i think it’s cool- more visualization means we’re closer to understanding other mechanisms…can never have enough good tooling!

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