Long non coding RNA activation with SAM V2 system

I would like to know if someone has tested the SAM V2 system to activate some long non coding RNA transcription .

I'm also interested if someone has tested this system in human embryonnic cells like H9 or H1 cells.


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Fuchsia Kelpieover 4 years ago

Thank you for your interest. I have used the SAM V2 system to activate lncRNA transcription (see Joung Nature 2017). I've also activated coding genes using the SAM V2 system in hESCs, but never tried activating lncRNAs in hESCs.

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